Quantitative Simulations Predict Treatment Strategies Against Fungal Infections in Virtual Neutropenic Patients
نویسندگان
چکیده
Research Group Applied Systems Biology, Leibniz Institute for Natural Product Research and Infection Biology—Hans Knöll Institute, Jena, Germany, Faculty of Biological Sciences, Friedrich Schiller University Jena, Jena, Germany, Center for Sepsis Control and Care (CSCC), Jena University Hospital, Jena, Germany, Fungal Septomics, Septomics Research Center, Leibniz Institute for Natural Product Research and Infection Biology—Hans Knöll Institute, Friedrich Schiller University, Jena, Germany, 5 Institute for Hygiene and Microbiology, University of Würzburg, Würzburg, Germany
منابع مشابه
Pattern of Bacterial and Fungal Infections in Neutropenic Pediatric Patients
Backgrounds: Neutropenia can be associated with life-threatening infections. Gram negative and staphylococcal infections are the most common pathogens. The spectrum of bacterial isolates has changed considerably over the past four decades. The objective of the present study was to evaluate the pattern of bacterial and fungal infections in neutropenic pediatric patients. Methods: A non-randomize...
متن کاملCandida infections among neutropenic patients
Background: Systemic candidiasis is a major complication in neutropenic cancer patients undergoing treatment. Most systemic fungal infections emerge from endogenous microflora so the aim of the present study was to identify Candida species isolated from the different regions of body in neutropenic patients in compare with the control group. Methods: A total of 309 neutropenic can...
متن کاملManagement of infection in the neutropenic patient.
Neutropenic patients continue to be at increased risk for developing serious infections despite substantial advances in supportive care. Epidemiologic shifts occur periodically and need to be detected early because they influence prophylactic, empiric, and specific therapy strategies. Although effective in preventing bacterial and some fungal infections, prophylaxis must be used with caution be...
متن کاملInvasive fungal infections in neutropenic enterocolitis: A systematic analysis of pathogens, incidence, treatment and mortality in adult patients
BACKGROUND Neutropenic enterocolitis is a life-threatening complication most frequently occurring after intensive chemotherapy in acute leukaemias. Gramnegative bacteria constitute the most important group of causative pathogens. Fungi have also been reported, but their practical relevance remains unclear. The guidelines do not address concrete treatment recommendations for fungal neutropenic e...
متن کاملThe expenditures related to the use of antifungal drugs in patients with hematological cancers: a cost analysis
OBJECTIVE The aim of this study is to analyze the expenditures related to the use of antifungal drugs in patients with hematological malignancies. METHODS In this retrospective study, the expenditures related to use of antifungal drugs for treatment of invasive fungal infections in patients with hematological malignancies between November 2010 and November 2012 were analyzed. Expenditures of ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره شماره
صفحات -
تاریخ انتشار 2018